The best labs to get and how to interpret them

This week, Paul breaks down his latest set of bloodwork from March 2023. He not only reviews his own levels and ratios, but gives you an idea of what blood work you may want to order, and how to interpret it.

00:00:00 Podcast begins
00:04:20 Why you may consider getting your own blood work done
00:11:00 What Paul eats in a day
00:13:40 Fasting insulin & prolactin
00:19:55 Cortisol to DHEA-S ratio
00:27:42 Sex hormones & phlebotomy
00:37:35 DHT
00:40:35 How to help (or hurt) your testosterone
00:48:45 Uric acid & GGT
00:50:30 Hemoglobin A1c & Comp. Metabolic Panel
00:53:20 Urinalysis
00:54:50 Amenorrhea profile, Prostate-Specific Ag, IGF-1, Reverse T3, Vitamin D, Lipoprotein (a), C-Reactive Protein
00:58:17 TMAO: is it harmful?
00:59:25 Homocysteine, Magnesium, and TSH & Free T4
01:00:50 Lipids: do they matter?
01:05:20 CBC
01:06:20 Conclusions about blood work
01:07:45 NAFLD

References:

Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://eje.bioscientifica.com/view/journals/eje/163/2/285.xml

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features: https://pubmed.ncbi.nlm.nih.gov/11445478/

The Effect of Macronutrients on Reproductive Hormones in Overweight and Obese Men: A Pilot Study: https://pubmed.ncbi.nlm.nih.gov/31847341/

Relationships between types of fat consumed and serum estrogen and androgen concentrations in Japanese men: https://pubmed.ncbi.nlm.nih.gov/11525593/

Effects of peppermint teas on plasma testosterone, follicle-stimulating hormone, and luteinizing hormone levels and testicular tissue in rats: https://pubmed.ncbi.nlm.nih.gov/15302514/

Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones: https://pubmed.ncbi.nlm.nih.gov/18804513/

Trans fatty acid intake is inversely related to total sperm count in young healthy men: https://pubmed.ncbi.nlm.nih.gov/24419496/

The effects of soy and whey protein supplementation on acute hormonal responses to resistance exercise in men: https://pubmed.ncbi.nlm.nih.gov/24015701/

Human sperm displays rapid responses to diet: https://pubmed.ncbi.nlm.nih.gov/31877125/

Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792795/

Dietary fat stimulates development of NAFLD more potently than dietary fructose in SpragueDawley rats: https://www.researchgate.net/publication/322679373_Dietary_fat_stimulates_development_of_NAFLD_more_potently_than_dietary_fructose_in_Sprague-Dawley_rats

High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats: https://pubmed.ncbi.nlm.nih.gov/26399510/

Excess dietary fructose does not alter gut microbiota or permeability in humans: A pilot randomized controlled study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358846/

Effects of Dietary Fructose, Sucrose and Lactose in Induction of Nonalcoholic Fatty Liver in Rat: https://citeseerx.ist.psu.edu/document?repid=rep1& ;type=pdf&doi=605cdff06b2414702779d09ab6b258e2a3bcad3f

Pauls recommendations for what labs you should get:
CBC
Comprehensive Metabolic Panel
Fasting Insulin
PTH
Full thyroid panel, TSH, antibodies, Free T3, Free T4, Testosterone, Free Testosterone, Sex hormone LH, FSH, Prolactin, DHT, Estrogens, Progesterone, Preglinulone, Cortisol, DHEA-S, HSCRP, Liver enzymes, Lipid panel, (Coronary Artery Calcium Scan), PTH.

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